Lantheus Medical Imaging, Inc. Presents Preliminary Data Comparing Novel Cardiac PET Imaging Agent With SPECT at SNM Annual Meeting

N. BILLERICA, Mass., Jun 07, 2010 (BUSINESS WIRE) -- Lantheus Medical Imaging, Inc., a worldwide leader in diagnostic medical imaging, today announced preliminary data from a single site participating in the multicenter Phase 2 clinical trial that showed that Positron Emission Tomography (PET) imaging with its novel investigational agent flurpiridaz F 18 injection (formerly known as BMS747158) provided better image quality than technetium-99m sestamibi single photon emission computed tomography (SPECT), the current standard for the non-invasive detection of coronary artery disease (CAD). The data also indicated that PET imaging with flurpiridaz F 18 injection rendered a significantly larger perfusion defect size when compared with the corresponding defects seen in SPECT imaging. The data were featured today in an oral presentation (# 798032) by Balaji Tamarappoo, M.D., Clinical Fellow, Advanced Cardiac Imaging at Cedars-Sinai Medical Center, at the SNM 57th Annual Meeting in Salt Lake City.

"These encouraging preliminary data from our clinical research site show that PET imaging with flurpiridaz F 18 injection provided improved image quality and an increase in defect size compared to SPECT," said Daniel S. Berman, M.D., Chief, Cardiac Imaging and Nuclear Cardiology, Cedars-Sinai Medical Center. "A PET imaging agent that may provide higher quality images with more obvious perfusion defects can have a profound effect on physicians' ability to make more definitive assessments of coronary artery disease."

source: MarketWatch

Siemens Celebrates 1000th MAGNETOM Espree MRI System

Malvern, Pa., June 3, 2010 – Siemens celebrates the milestone of the 1,000th MAGNETOM® Espree system sold worldwide with Barnes-Jewish Hospital in St. Louis, which is ranked among the top 10 hospitals in the United States and is the largest teaching hospital in Missouri. This installation marks the third MAGNETOM Espree that the 1,259-bed hospital will employ to image patients of all sizes, ages and disabilities.

“We are extremely pleased with the Espree scanners,” says Dr. Vamsi Narra, a Washington University radiologist on staff at Barnes-Jewish Hospital. “The wide bore configuration allows us to accommodate patients of all sizes, while providing top-notch imaging. More and more patients prefer the Espree to other standard-bore scanners.”

The 1.5 Tesla MAGNETOM Espree revolutionized the industry when it was introduced in 2004 as the world’s first Open Bore system. As a trailblazer in Open Bore technology, it combines the largest magnet bore – 70 cm – with the shortest magnet length – 125 cm cover to cover. This unique design provides 30 cm space above the patient’s face – twice that typically offered by vertical field open MRI systems. The very short length allows for 60 percent of exams to be completed with the patient’s head outside of the bore. The expanded face space and head-out scanning has proven to increase patient acceptance.

source: Siemens Healthcare

PET Scanning Probes Reveal Different Cell Function Within the Immune System

ScienceDaily (June 2, 2010) — A commonly used probe for Positron Emission Tomography (PET) scanning and a new probe developed by researchers at UCLA reveal different functions in diverse cells of the immune system, providing a non-invasive and much clearer picture of an immune response in action.

The probes, the commonly used FDG that measures cellular glucose metabolism, and FAC, developed at UCLA and which measures the activity of a distinct biochemical pathway, work better when used in combination than either does alone. In addition to revealing the extent and cellular composition of an immune response, the probes also may be useful in evaluating therapies that target different cellular components of the immune system, said Dr. Owen Witte, a professor of microbiology, immunology and molecular genetics, a Howard Hughes Medical Institute investigator and senior author of the study.

"We demonstrated with this study that each probe targets different cells in the immune system with a high degree of specificity," said Witte, director of the UCLA Broad Stem Cell Research Center and a Jonsson Cancer Center researcher.

source: Science Daily (Release)

Toshiba's Large Open Bore Mr System Improves Workflow At Overlake Hospital

TUSTIN, Calif., May 26, 2010 – Improving MR exam workflow without sacrificing patient safety, exam comfort or image quality is a goal for many health care facilities. Overlake Hospital in Bellevue, Wash., selected Toshiba America Medical Systems’ patient-friendly Vantage TitanTM ultra-short, open bore MR system to achieve this goal in its new MR facility.

Before acquiring the Titan, Overlake did not own an MR system and therefore was required to outsource all of its MR exams, a time-consuming and cumbersome experience for both the patient and physician. Since installing the Titan, Overlake patients receive MR exams immediately and on-site. In fact, the Titan’s ability to increase patient throughput because of its patient-friendly features enabled Overlake to exceed its patient volume projections shortly after installation.

“When planning our new MR department, we wanted to not only have around-the-clock access to MR exams and improve workflow, but also maintain Overlake’s focus on patient safety and comfort,” said Brenda Rinehart, director of Medical Imaging, Overlake Hospital. “The Titan’s features met and even exceeded these requirements. One example is the Titan’s large, open bore and noise reduction technology, which have improved the exam experience for our claustrophobic patients. This has resulted in a decrease in the need for sedation, allowing us to image patients more rapidly and safely.”

source: Toshiba Medical

MRI Research Highlights High-risk Atherosclerotic Plaque Hidden in the Vessel Wall

Researchers from Boston University School of Medicine (BUSM) have shown that use of magnetic resonance imaging (MRI) in an animal model can non-invasively identify dangerous plaques. The findings, which appear in the May issue of Circulation Cardiovascular Imaging, offer possible applications in the diagnosis and treatment of patients with atherosclerosis.

Rupture of vulnerable atherosclerotic plaque, which often occurs without prior symptoms, is responsible for a substantial number of deaths and disabilities worldwide. The untimely death of television journalist Tim Russert was caused by the sudden rupture of a vulnerable plaque in a critical location in a coronary artery. Identification of atherosclerotic plaques with a high risk for disruption and thrombosis would allow preventive therapy to be initiated before thrombi begin to clog arteries and cause stroke or heart attack.

The BUSM researchers examined diagnostic protocols in an animal (rabbit) model of human disease with procedures that never could have been applied to humans. Plaque disruption was stimulated at a precise time to allow MRI imaging before and after the rupture. According to researchers, plaques that were hidden within the vessel wall and pushing the vessel wall outward instead of occluding the lumen had a very high chance of forming a thrombus; plaques that caused vessel narrowing were almost always stable, which could explain why the most dangerous plaques generally escape detection by x-ray angiography. The study finds accurate, non-invasive MRI can identify these stable and unstable plaques.

source: Boston University School of Medicine

Symposium Focuses on Patient Safety in CT Scanning

ATLANTA, GA (May 13, 2010) -- A national summit of medical professionals meeting last month in Atlanta called for the creation of consensus scan techniques as a way of addressing the concerns of patients undergoing CT scans -- a common medical imaging procedure that uses X-rays to show cross-sectional images of the body.

The summit brought together some of the world's leading experts in CT imaging, including medical physicists, radiologists, technologists, and equipment manufacturers. It was hosted by the American Association of Physicists in Medicine (AAPM), a professional organization whose members include board-certified health professionals and research scientists specializing in the use of radiation in medicine.

According to Cynthia McCollough, Ph.D., Professor of Radiologic Physics at the Mayo Clinic, who co-organized the meeting on behalf of AAPM, the summit achieved its goal of identifying several issues that need to be dealt with by the medical imaging community in order to address the safety concerns of patients at U.S. hospitals and clinics.

In the last several months, many medical physicists have witnessed first-hand how some patients have grown concerned about stories in the media questioning the risks and challenging the safety of CT scans.

"We all hear it every day. Patients ask, 'do I really need to have this procedure?'," said Dianna Cody, Ph.D., another co-organizer of the meeting. Cody, who is Professor of Imaging Physics at the University of Texas M. D. Anderson Cancer Center, says that patients should not be afraid of getting medically appropriate CT exams. “When medically justified,” she said, “the benefits of CT scans far outweigh the risks.”

Even so, patients' fears are very real. The CT Dose Summit arose partly as a response to these fears, as leaders within the AAPM CT community discussed what more professionals in their field could do to ensure patient safety and to reassure patients coming for CT.

source: AAPM

Meet Phannie, NIST's Standard 'Phantom' for Calibrating MRI Machines

Magnetic resonance imaging (MRI)--a widely used medical tool that relies on magnetic fields and radio waves to visualize the body's internal structures, especially soft tissues--may soon become even more useful.

Phannie is the first “phantom” for calibrating magnetic resonance imaging (MRI) machines that is traceable to standardized values. The plastic sphere is about the size of a person’s head and filled with 100 smaller spheres used as contrast-enhancing agents and measurement reference markers. NIST researchers in Boulder, Colo., built Phannie and tested it on an MRI scanner at the University of Colorado Brain Imaging Center.

The National Institute of Standards and Technology (NIST) has unveiled the first “phantom” for calibrating MRI machines that is traceable to standardized values. The prototype, named Phannie, was developed in collaboration with the standards committee of the International Society for Magnetic Resonance in Medicine (ISMRM).

Traceable MRI calibrations are expected to enable accurate, quantitative measurements of tumors and other disease markers that can be reproduced across many different patients, scanners and clinics over time—and potentially reduce medical costs.

Displayed at the annual ISMRM meeting this past week,* the NIST phantom is a plastic sphere about the size of a person’s head, filled with water-bathed grids of 100 small plastic spheres containing various salt solutions that become magnetized in a magnetic field. By making MRI scans of Phannie, users can evaluate the image contrast, resolution, and accuracy of distance and volume measurements. A machine’s performance can be compared to standards, to other MRI machines, and to itself over time.

source: NIST

UF receives $7.5 million to study MRI as a tool for evaluating patients with Duchenne muscular dystrophy

GAINESVILLE, Fla. — Duchenne muscular dystrophy research at the University of Florida got a major boost with the award of $7.5 million in National Institutes of Health funding to study the use of magnetic resonance imaging in determining the natural progression of the disease.

UF scientists will assess whether MRI technology can be used as a precise, noninvasive measure of muscle tissue in children with Duchenne muscular dystrophy. Understanding how the disease affects muscle tissue could help facilitate the testing of new therapies in clinical trials, researchers say.

Duchenne muscular dystrophy affects about one of every 3,500 to 5,000 boys born each year in the United States, according to the Centers for Disease Control and Prevention. The disease causes the muscles that control movement to progressively weaken and lose the ability to regenerate after an injury, eventually replacing critical muscle tissue with fat and collagen. By age 12, many patients need a wheelchair. As the disease advances, the heart and respiratory system are affected and patients often die of cardiorespiratory failure in their 20s.

source: University of Florida

Preoperative MRI Assists in Surgical Planning and Helps Spare Erectile Function After a Robotic Assisted Laparoscopic Prostatectomy

Preoperative prostate magnetic resonance imaging (MRI) can help urologic surgeons spare the neurovascular bundle (NVB) (which controls a man’s erectile function and continence) during a robotic assisted laparoscopic prostatectomy (RALP) for the treatment of prostate cancer, according to a study to be presented at the ARRS 2010 Annual Meeting in San Diego, CA.

RALP is becoming increasingly common for the treatment of prostate cancer. “However it is limited by a lack of haptic feedback (loss of sense of touch), a component urologic surgeons use to evaluate the NVBs and determine if a nerve-sparing technique is possible,” said Timothy McClure, MD, lead author of the study. “Our study investigated the utility of MRI of the prostate in changing surgical decision making with regards to nerve sparring RALP,” said McClure.

The study, performed at the University of California, Los Angeles, included 104 men with biopsy proven prostate cancer who underwent preoperative MRI prior to RALP. “Twenty-nine out of 104 patients had the nerve sparring technique changed because of MR imaging. Of patients for whom the plan was changed, 49 percent underwent nerve sparing surgery and 40 percent had their plan changed to non-nerve sparing surgery,” said McClure.

source: ARRS

CT Technique Eliminates the Need for X-rays in Trauma Patients With Possible Spinal Fractures

When trauma patients receive a computed tomography (CT) scan of the chest, abdomen, and pelvis, a technique called CT spine reformatting eliminates the need for X-rays of the thoracic and/or lumbar spine to detect spinal fractures. This technique can lower cost and overall patient radiation exposure, according to a study to be presented at the ARRS 2010 Annual Meeting in San Diego, CA.

CT spine reformatting is performed by a CT technician after a CT scan is complete. It helps the radiologist assess the thoracic and/or lumbar regions of the spine without additional imaging, which can reduce cost and patient radiation exposure.

“Background research shows that CT is much more sensitive and specific than X-rays in detecting thoracic and lumbar spine fractures,” said Viesha Ciura, MD, lead author of the study. Our study looked at the percentage of trauma patients who had both reformatted CT data and X-rays of the thoracic and/or lumbar region of the spine and the additional radiation dose and cost associated with the unnecessary X-rays,” said Ciura.

The study, performed at the University of Calgary, Foothills Medical Centre, included 897 trauma CT scans with spine reformats. 19 percent of the patients with reformatted CT data showing the spine also had X-rays of the same segment of the spine. “In patients with spinal fractures detected on the CT spine reformats, the X-rays provided no additional information, and in fact, some of these fractures were not seen on the X-rays,” said Ciura. “Our calculations suggest that in every 1,000 trauma patients, the added radiation dose from spine X-rays that may not have been needed is 170 mSv; the additional cost per 1,000 trauma patients was $19,678.93,” she said.

source: ARRS

Non-Contrast HiSS MRI Performs Just as Well as Conventional Contrast-Enhanced MRI at Separating Benign and Malignant Breast Lesions

High spectral and spatial (HiSS) magnetic resonance imaging (MRI) — even when used without a contrast agent — matches the performance of conventional contrast-enhanced MRI at separating benign and malignant breast lesions, according to a study to be presented at the ARRS 2010 Annual Meeting in San Diego, CA. Contrast agents are used to enhance the image quality of an imaging exam.

HiSS MRI provides important functional and anatomical information that conventional MRI cannot. In addition, the image quality of HiSS MRI can be better than that of conventional MRI.

The study, performed at the University of Chicago in Chicago, IL, included 56 women who were imaged using both HiSS and conventional MRI. “Results showed that HiSS MRI (without contrast agents) performed just as well in the task of separating benign and malignant lesions as conventional MRI (with contrast agents),” said Milica Medved, MD, lead author of the study. “The accuracy of both tests was higher than 0.8,” she said.

“Currently, HiSS is still part of a research effort, and is not in routine clinical practice yet. We are hoping to change that — in fact, we are in the process of initiating a multi-center imaging trial which, if successful, would pave the way for routine clinical applications of HiSS,” said Medved.

source: ARRS

Image Filters Improve Image Quality and Lower Patient Radiation Dose Associated With CT Scans

Adaptive image filters can lower the patient radiation associated with chest and abdominal computed tomography (CT) scans while significantly improving image quality, according to a study to be presented at the ARRS 2010 Annual Meeting in San Diego, CA.

Image filters are one of the tools used in image processing to lower image “noise” in low radiation dose CT. “As we lower the radiation dose, the CT images become “noisy” or speckled which makes it difficult to view the organs or the body structures in the image,” said Sarabjeet Singh, MD, lead author of the study. “Image filters allow us to effectively lower the radiation dose without sacrificing the image clarity,” said Singh.

The study, performed at Massachusetts General Hospital in Boston, MA, included 12 patients who received a CT scan at four different levels of radiation dose in the chest and abdomen. All low dose images were processed with adaptive filters, and “regardless of radiation dose, post processing with image filters improved subjective noise for both chest and abdominal CT and helped lower the CT radiation dose levels for chest by up to 40 mAs and for the abdominal CT by up to 100 mAs,” said Singh.

“With the increasing use of CT, radiation dose concerns have been rising in the medical community, patients, as well as the media. Hence various efforts have been made to lower the radiation dose associated with CT scanning,” he said.

source: ARRS

Medtronic Launches Award-Winning Neuro Oncology Surgical Imaging System in the United States

MINNEAPOLIS– April 26, 2010 – Medtronic (NYSE: MDT) today announced U.S. Food and Drug Administration (FDA) 510(K) clearance and U.S. launch of the PoleStar® N30 Surgical MRI system, the latest in neuro oncology surgical solutions.

Providing real-time imaging in the operating room (OR), the PoleStar Surgical MRI provides surgeons with targeting and navigational accuracy despite the anatomy movement that may occur during a surgical procedure. With intra-operative imaging information, neurosurgeons gain more confidence to achieve maximum tumor resection, while avoiding critical areas of the brain. Use of the PoleStar system may also reduce the need for revision surgeries and the length of stay at the hospital for the patient.

“This is the next generation of intra-operative MRI providing flexibility, enhanced ergonomics and confidence in the achievement of surgical goals,” said Jim Cloar, vice president and general manager of the Navigation division, part of the Surgical Technologies business at Medtronic. “With its unique compact design, the PoleStar Surgical MRI system enables neurosurgeons to benefit from intra-operative MR imaging without the compromises inherent in other systems, such as extensive renovation of the operating room or restrictions upon the surgeons' choice of instruments.”

source: Medtronic

Researchers Successfully Lower Radiation Dose Associated With Pediatric Chest CT Scans

Adjusting the radiation dose based upon a child’s weight can significantly lower the radiation dose associated with pediatric chest computed tomography (CT) scans, according to a study published in the May issue of the American Journal of Roentgenology (www.ajronline.org). CT scanning combines special X-ray equipment with sophisticated computers to produce multiple images or pictures of the inside of the body.

The study, performed at Lucile Packard Children’s Hospital, Stanford School of Medicine, in Stanford, CA, included 120 children who underwent chest CT scans — 60 children weighed less than 15 kg (33 pounds) and 60 weighed between 15 and 60 kg (33 – 132 pounds). Radiologists adjusted their chest CT protocols by lowering the radiation dose according to patient weight.

“For children weighing less than 33 pounds, we were able to reduce the radiation dose by approximately 73 percent,” said Beverley Newman, MD, lead author of the study. “For children weighing between 33 and 132 pounds, we were able to reduce the radiation dose by approximately 48 percent,” said Newman.

“CT examinations are commonly performed in the pediatric population. However radiation dose related to CT has become a public health concern, and appropriate reduction of radiation dose has become an important goal in pediatric CT,” she said.

“While it is important to keep radiation doses as low as possible, it is important not to compromise the diagnostic usefulness of the scan. In our study, lowering the radiation dose did increase image noise resulting in grainy images. However the low dose examinations were still considered diagnostically acceptable,” said Newman.

source: ARRS

NIH Support For New Patented Technology For Improving Cardiac CTs

Cardiovascular disease is the leading cause of death globally and a tremendous burden on the healthcare system. Better detection of hardening or clogging of arteries and other blood vessels before symptoms occur is needed. With funding from the National Institutes for Health (NIH), researchers from Virginia Tech and GE Global Research Center are developing novel cardiac computed tomography (CT) architectures and methods, including a newly patented approach to a long-standing challenge in local CT image reconstruction (Patent 7,697,658 "Interior Tomography and Instant Tomography by Reconstruction from Truncated Limited-angle Projection Data" issued April 13, 2010). The research team will also evaluate the performance of various cardiac CT system designs to determine the most promising designs and demonstrate their clinical feasibility and utility.

Better image quality at lower radiation dose is the immediate need being addressed by the research project led by Ge Wang, the Pritchard Professor and director of the Biomedical Imaging Division of the Virginia Tech - Wake Forest University School of Biomedical Engineering & Sciences (SBES), and Bruno De Man, a CT authority at GE Global Research Center.

source: Medical News Today

New test could identify smokers at risk of emphysema

Using CT scans to measure blood flow in the lungs of people who smoke may offer a way to identify which smokers are most at risk of emphysema before the disease damages and eventually destroys areas of the lungs, according to a University of Iowa study.

The study found that smokers who have very subtle signs of emphysema, but still have normal lung function, have very different blood flow patterns in their lungs compared to non-smokers and smokers without signs of emphysema.

This difference could be used to identify smokers at increased risk of emphysema and allow for early intervention. The findings appear this week in the Early Edition of the Proceedings of the National Academy of Sciences.

"We have developed a new tool to detect early emphysema-related changes that occur in smokers who are susceptible to the disease," said lead study author Eric Hoffman, Ph.D., UI professor of radiology, internal medicine and biomedical engineering. "Our discovery may also help researchers understand the underlying causes of this disease and help distinguish this type of emphysema from other forms of chronic obstructive pulmonary disease. This type of CT scan could even be a tool to test the effectiveness of new therapies by looking at the changes in lung blood flow."

source: University of Iowa

Association Between CT, MRI Scans And Shorter Hospital Stays, Decreased Costs

Advanced imaging techniques such as computed tomography (CT) scans and magnetic resonance imaging (MRI) might shorten the length of a person's hospital stay and decrease the high costs associated with hospitalization if used early, according to a study in the April issue of the Journal of the American College of Radiology.

Inpatient costs represent 18 percent of total health care insurance premiums paid, and they continue to grow approximately 8 percent annually," said Juan Carlos Batlle, MD, MBA, lead author of the study. "The stable growth of hospital costs despite marked increases in imaging costs has led to the observation that the increased use of modern imaging has been associated with a decrease in other costs of hospitalization, such as length of stay, which our study seeks to demonstrate," said Batlle.

source: Medical News Today

Toshiba MR Technology Shortens Brain Imaging Time

TUSTIN, Calif., March 22, 2010 – When imaging the brain, time is critical as vascular abnormalities can have a profound effect on patients’ lives if not diagnosed quickly. To help health care facilities diagnose disease with greater accuracy and speed, Toshiba America Medical Systems, Inc. has introduced Variable True Rate Angiography with Combined Encodings (V-TRACE), an exclusive MRA sequence available on all Vantage TitanTM and Vantage Atlas® MR systems. V-TRACE streamlines MRA brain imaging by acquiring four image contrasts in one sequence, providing an imaging application for visualizing slow and fast flow vessels separately and together, as well as the brain tissue surrounding the vessels.

“The ability of Toshiba’s V-TRACE MRA sequence to image four contrasts in one sequence allows for greater visualization of blood vessels in the brain, particularly collateral vessels that can be difficult to see with standard MRA sequences,” said Doug Ryan, vice president, Marketing and Strategic Development, Toshiba. “This new sequence allows hospitals to improve workflow and patient care by saving time during MRA imaging.”

V-TRACE MRA is a dual-echo 3D FE sequence in which the first echo is acquired using Time-Of-Flight (TOF) and the second echo is acquired using Flow Sensitive Black Blood (FSBB). The sequence combines the advantages of both techniques to produce MRA images that depict blood vessels with both high and low velocity. The sequence design reduces the Specific Absorption Rate (SAR), which is a measurement of heat generated to the body during a MRI.

source: Toshiba Medical

Virtual Colonoscopy Allows Detection of Unsuspected Cancers Beyond Colon

ScienceDaily (Mar. 25, 2010) — A new, large-scale study of more than 10,000 adults found that more than one in every 200 asymptomatic people screened with CT colonography, or virtual colonoscopy, had clinically unsuspected malignant cancer and more than half of the cancers were located outside the colon. The findings were published in the April issue of the journal Radiology.

"We are finding that virtual colonoscopy screening actually identifies more unsuspected cancers outside of the colon than within it," said lead author Perry J. Pickhardt, M.D., professor of radiology and chief of GI Imaging, at the University of Wisconsin School of Medicine & Public Health. "As with asymptomatic colorectal cancers identified by virtual colonoscopy screening, these cancers are often detected at an early, curable stage."

Colorectal cancer remains the second leading cause of cancer death in the U.S., and the National Cancer Institute estimated that there would be 146,970 new cases diagnosed in 2009 and 49,920 deaths.

source: Science Daily Release

Unusual prenatal MRI detects rare, oft-missed genetic disease

(Media-Newswire.com) - In a case believed to be a United States first, the radiology team at Lucile Packard Children’s Hospital has used prenatal magnetic resonance imaging to detect an often-misdiagnosed genetic disease.

The disorder, congenital chloride diarrhea, can cause severe dehydration and serious metabolic disturbances in newborns if not treated quickly.

“This is a disease where early diagnosis is the key to a good outcome,” said Richard Barth, MD, the physician who recognized the unusual case. Congenital chloride diarrhea is so rare, with only about 250 total cases reported worldwide, that infants with the disease are often erroneously treated for other diarrhea-causing ailments. “If the patient’s fortunate, you could stumble onto this diagnosis,” said Barth, the chief radiologist at Packard Children’s and a professor of pediatric radiology at the School of Medicine. The case was the first instance of CCD Barth had ever seen.

It is one of only four known cases of CCD diagnosis ever made via prenatal MRI. A scientific report on the four cases, including Barth’s case and three from France, was published online Dec. 9 in the journal Ultrasound in Obstetrics & Gynecology. The report is a collaboration between Barth and a team of French scientists in Marseilles.

source: Media Newswire

Dual-Energy CT Accurately Diagnoses Gout in Acute, Emergency Settings

A medical imaging technique called dual-energy computed tomography (CT) is an effective and reliable way to diagnose gout in the acute, emergency setting, according to a study published in the April issue of the American Journal of Roentgenology (www.ajronline.org). Dual-energy CT is an advanced medical imaging technique that can detect vessels and bones and display them in clear contrast to one another. It enables physicians to diagnose many patients’ conditions faster and more accurately as it can better characterize tissue composition better than conventional CT.

Gout is an extremely painful kind of arthritis that occurs when uric acid builds up in and around the joints. “Doctors often use clinical features to diagnose gout, however many other diseases can mimic or coexist with it and conventional imaging techniques like X-rays, ultrasound, and conventional CT are not specific enough to facilitate a diagnosis,” said Savvakis Nicolaou, MD, lead author of the study.

The study, performed at Vancouver General Hospital in Vancouver, BC, included five cases in which the diagnosis for gout was made or excluded on the basis of dual-energy CT. “In every case, conventional imaging techniques were used before applying advanced dual-energy CT technology, however we were not able to make a diagnosis based solely upon those findings,” said Nicolaou.

“To our knowledge, dual-energy CT is the only imaging method described to date that can confirm the diagnosis of topheceaous (or chronic) gout with high accuracy,” he said.


source: ARRS

Medtronic Receives FDA Panel's Unanimous Recommendation for Approval of Revo MRI(TM) SureScan(TM) Pacing System

MINNEAPOLIS – March 19, 2010 – Medtronic, Inc. (NYSE: MDT) today announced that the U.S. Food and Drug Administration (FDA) Circulatory System Devices Panel of the Medical Devices Advisory Committee has voted unanimously in favor of approval with conditions of the Revo MRI™ SureScan™ pacing system designed as MR Conditional, or safe for use in Magnetic Resonance Imaging (MRI) systems under specified conditions. MRI procedures are not recommended in the United States for patients who currently have implanted pacemakers; if approved, Revo MRI has the potential to be the first FDA-approved pacing system designed for use in the MRI setting.

The FDA’s Circulatory System Devices Panel, which met today, recommended Revo MRI for approval with conditions related to the planned post-market study, health care professional training, and labeling to reflect MRI scans are to be conducted with the full Revo MRI SureScan Pacing System. The FDA will consider the panel’s recommendation in its review of Revo MRI; however, it is not bound by its Advisory Committee’s recommendations.

“MRI is critical in the diagnosis of many serious conditions; however, patients with current pacemakers most often do not have access to this vital technology,” said Pat Mackin, president of the Cardiac Rhythm Disease Management business and senior vice president at Medtronic. “The result of today’s panel brings Medtronic one step closer to helping address an important unmet patient need. We look forward to working with the FDA during the regulatory process so that we may provide certain pacemaker patients with access to MRI scans.”

source: Medtronic

Early Identification of Alzheimer's Disease With PET Scan

LOS ANGELES, March 16 /PRNewswire/ -- Westside Medical Associates of Los Angeles and Westside Medical Imaging (WMI) of Beverly Hills announce the benefit of early positron emission tomography (PET) scanning to identify Alzheimer's in its early more treatable phase. According to Dr. Norman Lepor, Professor of Medicine at the Geffen School of Medicine at UCLA and Co-director of Imaging at WMI, "the research investigators at the New York University Langone Medical Center have confirmed our long held belief that we can use advanced imaging for early identification of Alzheimer's disease in patients that have not yet developed symptoms." According to Dr. Lisa Moscone of the NYU Langone Medical Center, "treating at this early stage would have the best chance of success." According to Dr. Hooman Madyoon, Co-director of Imaging at WMI, "nearly 5 million Americans suffer from the debilitating effects of Alzheimer's with the number of Americans expected to be afflicted increasing to epidemic levels as the population ages."

According to Dr. Elliot Kolin, lead radiologist at WMI, "the NYU research team used PET with a fluorescent imaging agent called Pittsburgh Compound B that lights up clumps of a protein called beta amyloid that is a characteristic finding of Alzheimer's disease." According to Dr. Moscone not all patients with beta amyloid plaques in their brain develop Alzheimer's, the appearance of these plaques do increase the risk.

source: PR Newswire

Frost & Sullivan Lauds Positron Corporation For Cardiac-Focused PET Molecular Imaging Scanner Attrius™

Based on its recent analysis of the cardiac molecular imaging systems market, Frost & Sullivan recognizes Positron Corporation with the 2010 North American Award for New Product Innovation, for its pioneering cardiac positron emission tomography (PET) scanner, Attrius™. The Attrius™ was developed and optimized for molecular imaging of the heart, making it the ideal solution for cardiologists and hospitals looking to add high accuracy, cost effective imaging technology.

The nuclear cardiology imaging scene has been dominated by single photon emission tomography (SPECT) until recently when the imaging world was flipped upside down by the announcement of SPECT reimbursement cuts by the Centers for Medicare and Medicaid Services (CMS), combined with the world shortage of the molybdenum-99 isotope. Many in the industry are looking for new technologies to improve their diagnostic accuracy, improve patient outcomes, reduce patient radiation exposure all while adding to their bottom line. The elusive solution to this dire situation may lie in an already well established, underutilized imaging modality: PET.

source: Medical News Today

MRI Detects Contralateral Breast Tumours Missed by Conventional Screening Methods

JACKSONVILLE, Fla -- March 9, 2010 -- Scanning for contralateral breast cancer using magnetic resonance imaging (MRI) increases cancer detection rates among postmenopausal women, including those over 70 years old, with newly diagnosed breast cancer. The same findings were not confirmed in premenopausal women with newly diagnosed breast cancer.

Researchers at the Mayo Clinic, Jacksonville, Florida, found that 3.8% of 425 women had breast cancer in the undiagnosed breast that had not been detected with a clinical or mammographic examination; all were postmenopausal. In these women, detecting and treating cancer in both breasts at the same time may save costs, patient stress, and the potential toxicity that may come from having to treat cancer later in the second breast once it is discovered, the researchers say in the March/April issue of The Breast Journal.

Of particular interest to the researchers is their finding that patients aged >= 70 years had a higher prevalence of cancer in the second breast detected by MRI than did younger patients in the study. MRI detected a cancer in the second breast in 5.4% of 129 elderly women included in the study.

source: Doctors Guide

Study: CT cost-effectively screens for lung disease in non-smoking women

Performing a high-resolution CT on non-smoking women age 24 to 53 with a collapsed lung can be a cost-effective screening for lymphangioleiomyomatosis (LAM), according to a study published online Feb. 18 in the American Journal of Respiratory and Critical Care Medicine.

LAM, a rare lung disease, occurs when cells begin to grow and spread to the lungs, kidneys, lymph nodes and vessels. "Women with LAM who first experience spontaneous lung collapse will, on average, experience two more,” according to Brent Kinder, MD, the study's senior investigator.

Kinder and colleagues of the University of Cincinnati in Ohio evaluated the cost-effectiveness of screening patients for LAM by evaluating the rates of spontaneous pneumothorax and the prevalence of LAM in relation to age, gender and smoking status. The researchers used 2007 Medicare data.

According to the authors, the prevalence of LAM in non-smoking women between the ages of 25-54 with spontaneous pneumothorax is estimated
at 5 percent, based on available literature.

source: HealthImaging

Ownership/Leasing Of PET Scanners By Nonradiologists On The Rise

Just as with computed tomography (CT) and magnetic resonance imaging (MRI), the growth rate among non-radiologists who own or lease positron emission tomography (PET) equipment is also on the rise, contributing significantly to the ongoing issues surrounding self-referral and unnecessary utilization of imaging in the United States, according to a study published in the March issue of the Journal of the American College of Radiology. PET is a relatively new technology that produces three-dimensional images of functional processes in the body. It is often used to diagnose certain types of cancer and heart disease.

"One of the well-known factors contributing to rising imaging costs is self-referral among non-radiologist physicians which has been shown to result in unnecessary utilization of imaging," said Rajan Agarwal, MD, MBA, lead author of the study. "This has made imaging one focus of concern as policymakers and third party payers look to cut health care costs," said Agarwal.

source: Medcal News Today

Toshiba's Contrast-Free MRA Techniques Improve Patient Safety At Little Company Of Mary

TUSTIN, Calif., Feb. 25, 2010 – In response to concern over gadolinium-based contrast agents, Little Company of Mary, a not-for-profit Catholic community hospital in Evergreen Park, Ill., wanted to provide the highest quality and safest MRA procedures to its patients. To accomplish this, the facility installed Toshiba America Medical Systems, Inc.’s Vantage Atlas® MR system and utilized the full suite of proprietary contrast-free MRA techniques. These contrast-free techniques proved so beneficial that Little Company of Mary now completes 98 percent of its MRA exams without contrast.

“Eliminating the use of gadolinium-based contrast agents, particularly for patients with renal impairment, is greatly improving patient safety for those undergoing MRA exams at Little Company of Mary,” said Kate Erickson, supervisor of CT and MRI, Little Company of Mary. “The image quality produced using the contrast-free techniques is equal to or better than typical contrast-enhanced MRA exams.”

Erickson also added that Toshiba’s techniques are improving hospital efficiency. For example, by not using contrast the team has reduced the need for rescans that sometimes occurs when a bolus is missed, and they also do not need to run pre-exam lab tests on patients to evaluate renal function.

source: Toshiba Medical